CD14 binds LPS and is found on which cells?

CD14 binds LPS and is found on which cells?

• A. Macrophages
• B. B cells
• C. Neutrophils
• D. T lymphocytes

Answer: (A)

CD14 serves as a co-receptor for lipopolysaccharide (LPS) detection, working with the TLR4/MD-2 complex to trigger innate immune signaling and cytokine production. Its expression is highest on monocytes and tissue macrophages, making these cells the primary responders to LPS. B and T lymphocytes do not express CD14, so they aren’t the main cells involved in LPS recognition via CD14. Neutrophils can have some CD14, but the classic and most prominent location is macrophages. Therefore, macrophages are the cells where CD14 binds LPS.

CD14 serves as a co-receptor for lipopolysaccharide (LPS) detection, working with the TLR4/MD-2 complex to trigger innate immune signaling and cytokine production. Its expression is highest on monocytes and tissue macrophages, making these cells the primary responders to LPS. B and T lymphocytes do not express CD14, so they aren’t the main cells involved in LPS recognition via CD14. Neutrophils can have some CD14, but the classic and most prominent location is macrophages. Therefore, macrophages are the cells where CD14 binds LPS.